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Welcome to the Laboratory of Molecular and Biochemical Pharmacology (LFBM). Our group focuses on the pharmacological characterization of synthetic and natural compounds, with a particular emphasis on research related to neurodegenerative diseases. We conduct behavioral, biochemical, and molecular analyses to evaluate these compounds' effects. Additionally, our team actively explores pharmacogenetics as another key area of research.

Located in the Department of Pharmacology at the Institute of Biological Sciences (ICB) at the Federal University of Goiás (UFG), we collaborate extensively with researchers from several institutions in Brazil and abroad.

CONTACT

Mon, 25 Nov 2013 23:20:56 -0200

E-mail:

pcghedini@gmail.com

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USEFUL LINKS

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RESEARCH AREAS

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Pharmacogenetics and Molecular Genetics

Pharmacologic Mechanisms of Action of Synthetic and Natural Molecules

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PUBLICATIONS

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Articles in journals:

Fajemiroye, James Oluwagbamigbe ; MARTINS, JOSÉ LUÍS RODRIGUES ; GHEDINI, PAULO CÉSAR ; GALDINO, PABLINNY MORREIRA ; Paula, Joelma Abadia Marciano de ; REALINO DE PAULA, JOSÉ ; DA ROCHA, FABIO FAGUNDES ; Costa, Elson Alves . Antidepressive-Like Property of Dichloromethane Fraction of Pimenta pseudocaryophyllus and Relevance of Monoamine Metabolic Enzymes. Evidence-Based Complementary and Alternative Medicine (Online), v. 2013, p. 1-7, 2013.

PINHEIRO, D. S. ; ROCHA FILHO, C. R. ; MUNDIM, C. A. ; MARCO JUNIOR, P. ; ULHOA, C. J. ; REIS, A. A. S. ; GHEDINI, P. C. . Evaluation of Glutathione S-Transferase GSTM1 and GSTT1 Deletion Polymorphisms on Type-2 Diabetes Mellitus Risk. Plos One, v. 8, p. e76262, 2013.

LINO, F. M. A. ; SA, L. Z. ; TORRES, I. M. S. ; ROCHA, M. L. ; DINIS, T. C. P. ; GHEDINI, P. C. ; SOMERSET, V. S. ; GIL, E. S. . Voltammetric and spectrometric determination of antioxidant capacity of selected wines. Electrochimica Acta, v. 113, p. in press, 2013.

Fajemiroye, James Oluwagbamigbe ; Galdino, Pablinny Moreira ; Alves, Suzana Fereirra ; Paula, Joelma Abadia Marciano de ; Paula, José Realino de ; Ghedini, P.C. ; Costa, Elson Alves . Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus. Journal of Ethnopharmacology, v. 141, p. 872-877, 2012.

Citações:1

Sousa, F.B. ; Martins, J.L.R. ; Fiorentino, I.F. ; ; Nascimento, M.V.M. ; Galdino, P.M. ; Ghedini, P.C. ; de Paula, J.R. ; Costa. E.A. . Preliminary studies of gastroprotective effect of Celtis iguanaea (Jacq.) Sargent leaves (Ulmaceae) . Natural Product Research (Print), v. ifirst, p. 1-6, 2012.

Oliveira, L.M. ; Rodrigues, A.G. ; Silva, E.F. ; Cerqueira, L.B. ; ; Pedrino, G.R. ; Carvalho, M.H.C. ; ; Costa. E.A. ; Campos, F.R. ; Filgueira, F.P. ; Ghedini, P.C. . Endothelium-dependent vasorelaxant effect of butanolic fraction from Caryocar brasiliense Camb. leaves in rat thoracic aorta. Evidence-Based Complementary and Alternative Medicine (Print), v. 2012, p. ID 934142, 2012.

GHEDINI, PAULO CÉSAR ; Avellar, Maria Christina W. ; De Lima, Thereza Christina M. ; ; LAPA, Antônio José ; . Quantitative changes of nicotinic receptors in the hippocampus of dystrophin-deficient mice. Brain Research, v. 1483, p. 96-104, 2012.

Ghedini, P.C. ; ; ; . Presence of mRNA of muscle nicotinic acetylcholine receptor subunits and an ?-subunit splice variant in the mouse brain. Brain Research Bulletin, v. 81, p. 453-457, 2010.

; Ghedini, P.C. ; ; ; . Upregulation of muscle nicotinic acetylcholine receptor in the dystrophic (mdx) mouse.. Journal of Molecular Neuroscience, v. 40, p. 261-263, 2010.

Citações:1

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GHEDINI, P. C. ; Viel, Tânia A. ; ; Avellar, Maria Christina W. ; Godinho, Rosely O. ; ; ; . Increased expression of acetylcholine receptors in the diaphragm muscle of mdx mice . Muscle & Nerve (Print), v. 38, p. 1585-1594, 2008.

Citações:7 |9

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GHEDINI, P. C. ; . Butanolic extract of Aster squamatus aerial parts is the active fraction responsible to the antiulcer and gastric acid antisecretory effects.. Acta Farmaceutica Bonaerense, v. 26, p. 889-892, 2007.

Citações:1 |1

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; GHEDINI, P. C. ; DORIGONI, P. A. ; ; ; ; CASSOL, R. ; MATOS, R. S. ; FRÓES, L. F. ; . Cicatrização de feridas cutâneas em ratos tratados com pomada caseira à base de plantas medicinais. Revista Brasileira de Plantas Medicinais, Botucatu, v. 5, n.2, p. 91-97, 2003.

Citações:1

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; ; GHEDINI, P. C. ; ; PEREIRA, M. C. F. ; HUBER, S. ; SILVA, J. E. P. ; LOPES, S. . Oral subchronic toxicity of aqueous crude extract of Plantago australis leaves. Journal of Ethnopharmacology, EUA, v. 88, n.1, p. 15-18, 2003.

Citações:9 |13

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; GHEDINI, P. C. ; ; ; ; LENZI, C. F. ; ; . Effect of Plantago australis leaves on different gastric ulcer models. Revista Brasileira de Farmacognosia, Maringá/Pr, v. 12, n.supl., p. 113-114, 2002.

Citações:1

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; ; GHEDINI, P. C. ; ; . Analgesic and anti-inflammatory properties of Plantago australis hydroalcoholic extract. Acta Farmaceutica Bonaerense, La Plata, v. 21, n.2, p. 89-92, 2002.

Citações:5

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GHEDINI, P. C. ; ; ; ; ; . Preliminary Studies of Anti-Ulcerogenic Effect of Aster squamatus Leaves Hydroalcoholic Extract on Various Ulcer Models in Rats. Acta Farmaceutica Bonaerense, La Plata, v. 21, n.3, p. 165-168, 2002.

Citações:3

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; ; GHEDINI, P. C. ; . Evaluation of the acute toxicity of the aqueous crude extract of leaves of Plantago australis Lam.. Revista Brasileira de Toxicologia, São Paulo, v. 15, n.1, p. 15-17, 2002.

Citações:1

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GHEDINI, P. C. ; DORIGONI, P. A. ; ; EHTUR, A. B. M. ; LOPES, A. M. V. ; . Levantamento de dados sobre plantas medicinais de uso popular no município de São João do Polêsine, RS. II - Emprego de preparações caseiras de uso medicinal. Revista Brasileira de Plantas Medicinais, Botucatu, v. 5, n.1, p. 46-55, 2002.

Citações:5

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DORIGONI, P. A. ; GHEDINI, P. C. ; FRÓES, L. F. ; BAPTISTA, K. C. ; EHTUR, A. B. M. ; ; ; ; LOPES, A. M. V. ; . Levantamento de dados sobre plantas medicinais de uso popular no município de São João do Polêsine, RS, Brasil. I - Relação entre enfermidades e espécies utilizadas. Revista Brasileira de Plantas Medicinais, Botucatu, v. 4, n.1, p. 69-79, 2001.

Citações:19

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LAB TEAM

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RESEARCHERS:

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Laboratório de Farmacologia Bioquímica e Molecular

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